Louise Cooper has been battling cancer for over twenty years. Her growing resentment towards her suburban life and her husband, Nat, compounded by his affair, have left her longing for the life she dreamed of having in her youth. Meanwhile her family are facing other challenges.

Her son Danny, a lawyer in San Francisco, has discovered his lover is growing obsessed with online sex, and her daughter, a lesbian protest-singer, announces herself pregnant after performing DIY artificial insemination with everyday kitchen utensils. This is a rich exploration of a family facing inexorable change.